The New Tyre after the destruction of Tyre by Alexander the Great, In Ezekiel 26:3, the prophet said that Tyre, the Phoenician Empire’s most powerful city, would be attacked by many nations, because of its treatment of Israel. At about the time that Ezekiel delivered this prophecy, Babylon had begun a 13-year attack on Tyre’s mainland. Later, in about 332 BC, Alexander the Great conquered the island of Tyre and brought an end to the Phoenician Empire